THERAPEUTIC EFFECTS OF SUPEROXIDE-DISMUTASE DERIVATIVES MODIFIED WITH MONOSACCHARIDES OR POLYSACCHARIDES ON HEPATIC-INJURY INDUCED BY ISCHEMIA REPERFUSION

被引：91

作者：

FUJITA, T ^{[1
]}

FURITSU, H ^{[1
]}

NISHIKAWA, M ^{[1
]}

TAKAKURA, Y ^{[1
]}

SEZAKI, H ^{[1
]}

HASHIDA, M ^{[1
]}

机构：

[1] KYOTO UNIV,FAC PHARMACEUT SCI,DEPT BASIC PHARMACEUT,SAKYO KU,KYOTO 60601,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 189卷 / 01期

关键词：

D O I：

10.1016/0006-291X(92)91543-Y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Therapeutic effects of four types of recombinant superoxide dismutase (SOD) derivatives, conjugates with polysaccharides, carboxymethyl (SOD-CMD) and diethylaminoethyl (SOD-DEAED) dextrans and galactosylated (Gal-SOD) and mannosylated (Man-SOD) derivatives, on hepatic ischemia/reperfusion injury were studied in rats. Hepatic injury induced by transient occlusion and subsequent reflow of hepatic blood was evaluated by the analysis of biliary excretion of bromosulfophthalein (BSP) injected intravenously. At a dose of 10000 units/kg, native SOD and SOD-DEAE did not show any significant effect and SOD-CMD showed slight effect. On the other hand, Gal-SOD and Man-SOD, targeted to the liver parenchymal and nonparenchymal cells, respectively, by a receptor-mediated endocytosis, exhibited superior inhibitory effects. These results demonstrated that these glycosylated SOD derivatives were useful for the prevention of hepatic ischemia/reperfusion injury. © 1992.

引用

页码：191 / 196

页数：6

共 22 条

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