A MONOCLONAL-ANTIBODY DETECTS HETEROGENEITY IN VASCULAR ENDOTHELIUM OF TUMORS AND NORMAL-TISSUES

被引:176
作者
WANG, JM
KUMAR, S
PYE, D
VANAGTHOVEN, AJ
KRUPINSKI, J
HUNTER, RD
机构
[1] CHRISTIE HOSP & HOLT RADIUM INST, MANCHESTER M20 9BX, LANCS, ENGLAND
[2] IMMUNOTECH SA, MARSEILLE, FRANCE
关键词
D O I
10.1002/ijc.2910540303
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
A new murine monoclonal antibody (MAb), E-9, has been raised using tissue-cultured human umbilical vein endothelial cells. The antigen recognized by this MAb is a peptide of 170 kDa under non-reducing conditions and 96 kDa under reducing conditions. MAb E-9 showed marked heterogeneity in its distribution in various tissues. The antigen recognized by it was present in vascular endothelial cells of all tumours, foetal organs and in regenerating and inflamed tissues. It stained a few normal tissues. However, with the exception of tonsils, staining tended to be weak and limited to a few blood vessels, as revealed by double staining using pan-endothelial antibody (CD3 1) and antibody to von Willebrand factor, another marker of vascular endothelium. Surprisingly, blood vessels within the placental villi were completely negative. The function of the antigen recognized by MAb E-9 is not known, but its evaluation and use should increase our understanding of angiogenesis.
引用
收藏
页码:363 / 370
页数:8
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