A NEW VARIANT OF SEROSUBTYPE P1.16 IN NEISSERIA-MENINGITIDIS FROM NORWAY, ASSOCIATED WITH INCREASED RESISTANCE TO BACTERICIDAL ANTIBODIES INDUCED BY A SEROGROUP-B OUTER-MEMBRANE PROTEIN VACCINE

被引:31
作者
ROSENQVIST, E
HOIBY, EA
WEDEGE, E
CAUGANT, DA
FROHOLM, LO
MCGUINNESS, BT
BROOKS, J
LAMBDEN, PR
HECKELS, JE
机构
[1] UNIV SOUTHAMPTON,SOUTHAMPTON GEN HOSP,SCH MED,MOLEC MICROBIOL GRP,SOUTHAMPTON S09 4XY,ENGLAND
[2] NATL INST PUBL HLTH,DEPT BACTERIOL,N-0462 OSLO,NORWAY
关键词
NEISSERIA-MENINGITIDIS; CLASS-1; PROTEIN; EPITOPE; SEROSUBTYPE; GROUP-B VACCINE; BACTERICIDAL ANTIBODIES; MONOCLONAL ANTIBODIES;
D O I
10.1006/mpat.1993.1070
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Based on differences in reaction pattern with monoclonal antibodies against the P1.16 epitope, a new variant of the class 1 protein in Neisseria meningitidis serogroup B was identified in Norway. A single amino acid deletion was revealed when the part of the gene region encoding the second variable region of the protein was sequenced. This new variant was designated P1.16c. About 5% of the B:15:P1.7,16 strains in Norway from the time period 1987-1991 were P1.16c. In a localized area in Southern Norway, 5/8 (62%) of the P1.7,16 strains were P1.16c. The P1.16b mutant, recently described in England, was not found among the Norwegian meningococcal isolates. Strains carrying the P1.16c mutation showed increased resistance to bactericidal killing, not only by P1.16-specific monoclonal antibodies, but also by the sera from individuals immunized with a vaccine based on outer membranes from a B:15:P1.7,16 strain. © 1993 Academic Press. All rights reserved.
引用
收藏
页码:197 / 205
页数:9
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