REIDISPONGIOLIDE-A AND REIDISPONGIOLIDE-B, 2 NEW POTENT CYTOTOXIC MACROLIDES FROM THE NEW-CALEDONIAN SPONGE REIDISPONGIA-COERULEA

被引：61

作者：

DAURIA, MV

PALOMA, LG

MINALE, L

ZAMPELLA, A

VERBIST, JF

ROUSSAKIS, C

DEBITUS, C

PATISSOU, J

机构：

[1] UNIV NAPLES,DIPARTIMENTO CHIM SOSTANZE NAT,I-80131 NAPLES,ITALY

[2] SMAB,FAC PHARM,F-44035 NANTES,FRANCE

[3] ORSTOM,NOUMEA,NEW CALEDONIA

来源：

TETRAHEDRON | 1994年 / 50卷 / 16期

关键词：

D O I：

10.1016/S0040-4020(01)85019-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two new 26-membered macrolides, reidispongiolide A (1) and B (2), have been isolated from the New Caledonian marine sponge Reidispongia coerulea n.gen.n.sp. Levi and Levi and their structures elucidated. They are related to sphinxolides previously isolate;l from an unknown nudibranch and later from the sponge Neosiphonia superstes. 1 and 2 co-occurr with sphinxolide B (4) and D (3). These macrolides exhibited potent cytotoxicity against various human carcinoma cells.

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页码：4829 / 4834

页数：6

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