CYTOKINE PRODUCTION IN DRUG-FREE AND NEUROLEPTIC-TREATED SCHIZOPHRENIC-PATIENTS

被引：80

作者：

BESSLER, H

LEVENTAL, Z

KARP, L

MODAI, I

DJALDETTI, M

WEIZMAN, A

机构：

[1] BEILINSON MED CTR,FELSENSTEIN MED RES CTR,BIOL PSYCHIAT LAB,IL-49100 PETAH TIQWA,ISRAEL

[2] HASHARON HOSP,GOLDA MED CTR,HEMATOL RES LAB,PETAH TIQWA,ISRAEL

[3] HASHARON HOSP,GOLDA MED CTR,DEPT MED B,PETAH TIQWA,ISRAEL

[4] GEHA PSYCHIAT HOSP,RES UNIT,PETAH TIQWA,ISRAEL

[5] TEL AVIV UNIV,SACKLER FAC MED,IL-69978 TEL AVIV,ISRAEL

来源：

BIOLOGICAL PSYCHIATRY | 1995年 / 38卷 / 05期

关键词：

SCHIZOPHRENIA; PROLACTIN; NEUROLEPTICS; INTERLEUKIN (IL)-I-BETA; INTERLEUKIN-2; INTERLEUKIN IL-3-LIKE ACTIVITY;

D O I：

10.1016/0006-3223(94)00299-I

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A line of evidence indicates changes of the immune system in schizophrenic patients. We investigated the production of cytokines by peripheral blood mononuclear cells (PBMCs) in drug-free and neuroleptic-treated schizophrenic patients compared to healthy, normal controls. A significant reduction in interleukin (IL)-2 production was detected in untreated schizophrenic patients (-59.6%; p < .05) as well as in IL-3-like activity (IL-3-LA) production (-27.4%; p < .05) in treated patients compared to controls. No alteration was observed in IL-1 beta production. It seems that schizophrenia is associated with diminished IL-2 production, while neuroleptic treatment interferes with the capacity production did not correlate with either the severity of the discover or the serum prolactin levels.

引用

页码：297 / 302

页数：6

共 34 条

[1] DECREASED PRODUCTION OF AND RESPONSE TO INTERLEUKIN-2 BY CULTURED LYMPHOCYTES FROM PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS [J].