HORMONAL-THERAPY OF MALE HYPOGONADISM

Male hypogonadism occurs commonly in clinical practice and has significant effects on the well being of patients. For example, Klinefelter's syndrome, a primary testicular disorder, occurs in approximately 1 in 500 men and results in both androgen deficiency and infertility.(28) The clinical manifestations of male hypogonadism usually can be treated effectively. Androgen deficiency in men with Klinefelter's syndrome can be treated with testosterone replacement; however, the infertility is irreversible. In contrast, both androgen deficiency and infertility can be corrected using gonadotropin therapy in men with hypogonadotropic hypogonadism. Appropriate hormonal therapy of men with hypogonadism requires an understanding of the normal physiologic regulation of the testis and the pathophysiology underlying testicular dysfunction.