HIPPOCAMPAL SYNAPTIC PLASTICITY AS A BIOLOGICAL SUBSTRATE UNDERLYING EPISODIC PSYCHOSIS

被引:23
作者
PORT, RL
SEYBOLD, KS
机构
[1] GROVE CITY COLL, DEPT PSYCHOL, GROVE CITY, PA 16127 USA
[2] SLIPPERY ROCK UNIV, DEPT PSYCHOL, SLIPPERY ROCK, PA 16057 USA
关键词
SCHIZOPHRENIA; LTP; HIPPOCAMPUS; LIMBIC SYSTEM; PLASTICITY;
D O I
10.1016/0006-3223(94)00128-P
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Structural change in the hippocampal formation has become popular as a proposed neurobiological substrate for schizophrenic disorders. It is postulated that behavioral plasticity in the form of long-term potentiation of hippocampal synaptic transmission is an attractive putative mechanism for the mediation of transient psychosis. Moreover, the disturbed hippocampal neuroarchitecture found in schizophrenic brain may be susceptible to potentiation and dysfunctional to the degree that delusions and hallucinations develop. Partial and selective blockade of the receptors mediating potentiation may prove to be an efficient means of preventing psychotic episodes and avoiding further damage to the involved network. Basic research, utilizing experimental models such as intraventricular kainic acid injection, may help to clarify the anatomical and physiological substrate of psychosis.
引用
收藏
页码:318 / 324
页数:7
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