IS ALZHEIMERS-DISEASE AN APOLIPOPROTEIN-E AMYLOIDOSIS

被引：151

作者：

WISNIEWSKI, T

LALOWSKI, M

GOLABEK, A

VOGEL, T

FRANGIONE, B

机构：

[1] NYU,MED CTR,DEPT NEUROL,NEW YORK,NY 10016

[2] BIOTECHNOL GEN LTD,REHOVOT,ISRAEL

来源：

LANCET | 1995年 / 345卷 / 8955期

关键词：

D O I：

10.1016/S0140-6736(95)90701-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The presence of the apolipoprotein E4 allele has been identified as a major risk factor for late-onset Alzheimer's disease. Apolipoprotein E has also been found immunohistochemically in Alzheimer's disease lesions. We biochemically isolated amyloid beta from senile plaques and found that a carboxyl-terminal fragment (residues 216-299) of apolipoprotein E co-purified. In vitro this fragment from recombinant apolipoprotein E could form amyloid-like fibrils, which were Congo-red positive. Thus senile plaques may contain both amyloid beta and apolipoprotein E amyloid fibrils.

引用

页码：956 / 958

页数：3

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