DECREASED NATURAL-KILLER CELL-ACTIVITY AFTER PROLONGED ADMINISTRATION OF INTERFERON IN CANCER-PATIENTS

被引：12

作者：

CUELLAR, AB

RUIZ, JLM

ORBACHARBOUYS, S

机构：

[1] HOP PAUL BROUSSE, INST CANCEROL & IMMUNOGENET,CNRS,LAB 149, 14-16 AVE PAUL VAILLANT COUTURIER, F-94804 VILLEJUIF, FRANCE

[2] HOP PAUL BROUSSE, SERV MALAD SANGUINES & TUMORALES, F-94804 VILLEJUIF, FRANCE

来源：

IMMUNOLOGY LETTERS | 1985年 / 10卷 / 3-4期

关键词：

D O I：

10.1016/0165-2478(85)90067-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Two patients with metastatic neoplastic disease received 2-3 .times. 106 IU .alpha. recombinant interferon (IFN) 3 times/wk, every other week, for 3-6 mo. The natural killer (NK) activity of their peripheral blood leukocytes, was followed during the course of the treatment. A significant decrease was observed in the NK activity, which returned to normal values at the end of IFN administration. The treatment did not modify the formation of metastasis.

引用

页码：137 / 139

页数：3

共 12 条

[1] INTERFERONS AND THE IMMUNE-SYSTEM [J].

BLOOM, BR .

NATURE, 1980, 284 (5757) :593-595

[2] INTERFERON AND SPONTANEOUS CYTO-TOXICITY IN MAN .5. ENHANCEMENT OF SPONTANEOUS CYTO-TOXICITY IN PATIENTS RECEIVING HUMAN-LEUKOCYTE INTERFERON [J].

EINHORN, S ;

BLOMGREN, H ;

STRANDER, H .

INTERNATIONAL JOURNAL OF CANCER, 1980, 26 (04) :419-428

[3]

FERRARINI M, 1983, J CLIN IMMUNOL, V3, P30, DOI 10.1007/BF00919136

[4]

GOLUB SH, 1982, NK CELLS OTHER NATUR, P1265

[5]

GRESSER I, 1980, PROGR IMMUNOLOGY, P710

[6]

GRESSER I, 1970, JNCI-J NATL CANCER I, V45, P363

[7]

JORDAN UG, 1982, ANN INTERN MED, V96, P549

[8] EFFECT OF LEUKOCYTE INTERFERON ON NATURAL-KILLER CELLS IN HEALTHY-VOLUNTEERS [J].

KARINIEMI, AL ;

TIMONEN, T ;

KOUSA, M .

SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 1980, 12 (05) :371-374

[9]

LOTZOVA E, 1983, JNCI-J NATL CANCER I, V71, P903

[10]

MALUISH AE, 1983, J IMMUNOL, V131, P503

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