PEPTIDES AS CONFORMATIONAL SWITCH - MEDIUM-INDUCED CONFORMATIONAL TRANSITIONS OF DESIGNED PEPTIDES

被引：73

作者：

MUTTER, M

HERSPERGER, R

机构：

[1] Séction de Chimie, Université Lausanne, Lausanne, CH-1005

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 1990年 / 29卷 / 02期

关键词：

D O I：

10.1002/anie.199001851

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The synthetic oligopeptide I undergoes a spontaneous, reversible transition from an α‐helix to a β‐sheet structure in mixtures of 45% 2,2,2‐trifluoroethanol and 55% H2O. The amphiphilic oligopeptide 1 and two isomers were expressly designed for this investigation. Such peptides, which can exist in several conformations, might find application as “switches” in the de novo design of artificial proteins. (Formula Presented.) Copyright © 1990 by VCH Verlagsgesellschaft mbH, Germany

引用

页码：185 / 187

页数：3

共 34 条

[1] BARANY G, 1980, PEPTIDES, V2, P3
[2] MULTICONFORMATIONAL SYNTHETIC POLYPEPTIDES
BRACK, A
SPACH, G
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1981, 103 (21) : 6319 - 6323
[3] DETERMINATION OF PROTEIN SECONDARY STRUCTURE IN SOLUTION BY VACUUM ULTRAVIOLET CIRCULAR-DICHROISM
BRAHMS, S
BRAHMS, J
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1980, 138 (02) : 149 - 178
[4] Chou P Y, 1978, Adv Enzymol Relat Areas Mol Biol, V47, P45
[5] CREIGHTON TE, 1983, PROTEINS
[6] INDUCTION OF PEPTIDE CONFORMATION AT APOLAR WATER INTERFACES .1. A STUDY WITH MODEL PEPTIDES OF DEFINED HYDROPHOBIC PERIODICITY
DEGRADO, WF
LEAR, JD
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1985, 107 (25) : 7684 - 7689
[7] PROTEIN DESIGN, A MINIMALIST APPROACH
DEGRADO, WF
WASSERMAN, ZR
LEAR, JD
[J]. SCIENCE, 1989, 243 (4891) : 622 - 628
[8] EISENBERG D, 1986, Proteins Structure Function and Genetics, V1, P16, DOI 10.1002/prot.340010105
[9] GOODMAN M, 1974, PEPTIDES POLYPEPTIDE, P308
[10] HERSPERGER R, UNPUB

← 1 2 3 4 →