JANTHINOCIN-A, JANTHINOCIN-B AND JANTHINOCIN-C, NOVEL PEPTIDE LACTONE ANTIBIOTICS PRODUCED BY JANTHINOBACTERIUM-LIVIDUM .1. TAXONOMY, FERMENTATION, ISOLATION, PHYSICOCHEMICAL AND BIOLOGICAL CHARACTERIZATION

被引：21

作者：

OSULLIVAN, J

MCCULLOUGH, J

JOHNSON, JH

BONNER, DP

CLARK, JC

DEAN, L

TREJO, WH

机构：

[1] The Squibb Institute for Medical Research, NJ 08543-4000, P.O. Box 4000, Princeton

来源：

JOURNAL OF ANTIBIOTICS | 1990年 / 43卷 / 08期

关键词：

D O I：

10.7164/antibiotics.43.913

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Janthinocins A, B and C are novel antibacterial agents produced by Janthinobacterium lividum. They were isolated from fermentation broths and characterized by UV, IR, NMR and mass spectroscopy. They are cyclic decapeptide lactones with marked activity against aerobic and anaerobic Gram-positive bacteria and are 2 to 4 times more potent in vitro than vancomycin. Janthinocins A and B were also found to be effective in a Staphylococcus aureus systemic infection in mice. © 1990, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.

引用

页码：913 / 919

页数：7

共 5 条

[1] INHIBITION OF PEPTIDOGLYCAN BIOSYNTHESIS IN GRAM-POSITIVE BACTERIA BY LY146032 [J].