BIOTRANSFORMATION OF GLYCERYL TRINITRATE BY RAT AORTIC CYTOCHROME-P450

被引：56

作者：

MCDONALD, BJ ^{[1
]}

BENNETT, BM ^{[1
]}

机构：

[1] QUEENS UNIV,DEPT PHARMACOL & TOXICOL,KINGSTON K7L 3N6,ONTARIO,CANADA

来源：

BIOCHEMICAL PHARMACOLOGY | 1993年 / 45卷 / 01期

关键词：

D O I：

10.1016/0006-2952(93)90403-J

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Denitration of glyceryl trinitrate (GTN) by the microsomal fraction of rat aorta was found to be NADPH dependent and followed apparent first-order kinetics (T1/2 70.1 min). Biotransformation of GTN was regioselective for glyceryl-1,2-dinitrate formation, and was inhibited by carbon monoxide, SKF-525A, and oxygen. In aortic microsomes prepared from phenobarbital-pretreated rats, biotransformation was increased 7-fold, and was regioselective for glyceryl-1,3-dinitrate formation. These data strongly suggest the involvement of aortic cytochrome P450 in the biotransformation of GTN.

引用

页码：268 / 270

页数：3

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