HISPIDULIN PROTECTION AGAINST HEPATOTOXICITY INDUCED BY BROMOBENZENE IN MICE

被引：25

作者：

FERRANDIZ, ML

BUSTOS, G

PAYA, M

GUNASEGARAN, R

ALCARAZ, MJ

机构：

[1] UNIV VALENCIA, FAC PHARM, DEPT PHARMACOL, E-46100 BURJASSOT, SPAIN

[2] CTR POSTGRAD STUDIES, PONDICHERRY, INDIA

来源：

LIFE SCIENCES | 1994年 / 55卷 / 08期

关键词：

HISPIDULIN; FLAVONOID; BROMOBENZENE; HEPATOTOXICITY; LIPID PEROXIDATION; GLUTATHIONE;

D O I：

10.1016/0024-3205(94)00490-0

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The effects of the natural flavonoid hispidulin (6-methoxy-5,7,4'-trihydroxyflavone) on bromobenzene-induced hepatotoxicity in mice were investigated. We found a correlation between liver injury and hepatic lipid peroxidation besides a strong liver glutathione depletion due to the toxicant. Hispidulin at doses between 50 and 150 mg/kg i.p. compared favourably with the reference compound N-acetyl-L-cysteine for inhibition of liver injury and lipid peroxidation. The flavonoid at the highest dose tested was also able to counteract reduced glutathione depletion induced by bromobenzene in starved mice. These hepatoprotective effects can be related to the antioxidant properties of hispidulin.

引用

页码：PL145 / PL150

页数：6

共 27 条

[1]

ANON MT, 1992, Z NATURFORSCH C, V47, P275

[2]

Bors W, 1987, Free Radic Res Commun, V2, P289, DOI 10.3109/10715768709065294

[3] SILYBIN DIHEMISUCCINATE PROTECTS AGAINST GLUTATHIONE DEPLETION AND LIPID-PEROXIDATION INDUCED BY ACETAMINOPHEN ON RAT-LIVER [J].