THE FIRST ENANTIOSELECTIVE SYNTHESIS OF THE CHEMOTACTIC FACTOR SIRENIN BY AN INTRAMOLECULAR [2+1] CYCLIZATION USING A NEW CHIRAL CATALYST

被引：124

作者：

GANT, TG ^{[1
]}

NOE, MC ^{[1
]}

COREY, EJ ^{[1
]}

机构：

[1] HARVARD UNIV,DEPT CHEM,CAMBRIDGE,MA 02138

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 48期

关键词：

D O I：

10.1016/0040-4039(95)01924-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple, highly enantioselective synthesis of sirenin (1) (bioactive form) has been developed which depends on the intramolecular [2 + 1] cycloaddition reaction of diazo ester 5 to form bicyclic ester 6 (95:5 enantioselectivity) using a new and remarkably stable monomeric chiral Cu(I) complex (2) whose structure was proven by X-ray diffraction analysis.

引用

页码：8745 / 8748

页数：4

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