PREPARATION OF C-14-LABELED DIMETHYLSILANE-1,1-DIOL

被引：4

作者：

CELLA, JA

CARPENTER, JC

机构：

[1] General Electric Company Corporate Research and Development, Schenectady, New York, 12301, PO Box 8

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1994年 / 34卷 / 05期

关键词：

C-14; DIMETHYLSILANE 1,1-DIOL; PROTODESILYLATION;

D O I：

10.1002/jlcr.2580340504

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The preparation of C-14-labelled dimethylsilane-1,1-diol in two steps from C-14-labelled diphenyldimethylsilane is described. Aluminum chloride catalyzed protodesilylation of diphenyldimethylsilane with HCl in dichloromethane or dimethyldichlorosilane at 0-5 degrees C affords labelled dimethyldichlorosilane which is hydrolyzed in the presence of triethylamine to afford the title compound in 45-60% yield.

引用

页码：427 / 430

页数：4

共 14 条

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