A FIELD-EVALUATION OF THE EFFICACY OF TOLFENAMIC ACID AND OXYTETRACYCLINE IN THE TREATMENT OF BOVINE RESPIRATORY-DISEASE

被引:38
作者
DELEFORGE, J
THOMAS, E
DAVOT, JL
BOISRAME, B
机构
[1] Vetoqu1Nol Research Centre, Lure
关键词
D O I
10.1111/j.1365-2885.1994.tb00520.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
In a blinded multicentre trial 313 cattle showing clinical signs of respiratory disease were allocated randomly into three groups, treated intramuscularly with a long-acting oxytetracycline formulation at a dose rate of 20 mg/kg bodyweight in combination with vehicle alone (placebo) or with tolfenamic acid at 2 mg/kg bodyweight once or on two occasions with a 48-h interdosing interval. The clinical status of the animals was monitored for 5 days using a specific scoring system and weight gain was calculated between day 0 and day 21. Relapses were monitored from day 5 until day 21. When oxytetracycline was combined with two injections of tolfenamic acid, there was a significant (P < 0.04) improvement in the clinical resolution. This regimen also produced non-significant improvements in cure rate, reduced frequency of relapses and improved weight gain.
引用
收藏
页码:43 / 47
页数:5
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