EFFECT OF RUFLOXACIN UPON NONSPECIFIC IMMUNE DEFENSES - IN-VITRO, EX-VIVO AND IN-VIVO RESULTS

被引:17
作者
CUFFINI, AM [1 ]
TULLIO, V [1 ]
ALLOCCO, A [1 ]
PAIZIS, G [1 ]
DELEO, C [1 ]
CARLONE, NA [1 ]
机构
[1] SMITHKLINE BEECHAM PHARMACEUT,DEPT MED,MILAN,ITALY
关键词
D O I
10.1093/jac/34.4.545
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
This study investigated in-vitro, ex-vivo and in-vivo the immunomodulatory effects of rufloxacin. 0.5 MIC of rufloxacin significantly enhanced human macrophage phagocytosis and increased intracellular killing of Klebsiella pneumoniae in vitro. Pre-incubation of K. pneumoniae with rufloxacin made the bacteria more susceptible to both phagocytosis and intracellular killing by human macrophages than control organisms. Following pre-exposure of macrophages to 0.5 MIC of rufloxacin, there was a significant increase in the intracellular killing of K. pneumoniae compared with the controls, indicating the ability of rufloxacin to cross biological membranes and to remain active within phagocytes. Ex-vivo experiments show that iv administration of rufloxacin in mice lead to an increase in both phagocytic and microbicidal intracellular activity by phagocytes. In-vivo models of experimental infections showed that prophylactic administration of rufloxacin increased the survival of mice after challenge with Candida albicans.
引用
收藏
页码:545 / 553
页数:9
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