RETINOID-X RECEPTOR-ALPHA TRANSACTIVATES THE HEPATITIS-B VIRUS ENHANCER-1 ELEMENT BY FORMING A HETERODIMERIC COMPLEX WITH THE PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR

被引：58

作者：

HUAN, BF

KOSOVSKY, MJ

SIDDIQUI, A

机构：

[1] UNIV COLORADO,SCH MED,DEPT MICROBIOL,DENVER,CO 80262

[2] UNIV COLORADO,SCH MED,PROGRAM MOLEC BIOL,DENVER,CO 80262

来源：

JOURNAL OF VIROLOGY | 1995年 / 69卷 / 01期

关键词：

D O I：

10.1128/JVI.69.1.547-551.1995

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The hepatitis B virus enhancer 1 contains a retinoic acid responsive element (RARE). We have previously demonstrated that retinoid X receptor alpha (RXR alpha) transactivates enhancer 1 by binding to the RARE. The present study has revealed that a heterodimeric complex composed of RXR alpha and peroxisome proliferator-activated receptor (PPAR) interacts with the hepatitis B virus RARE. Transient transfection studies in conjunction with in vitro DNA binding data, support the hypothesis that the RXR alpha-PPAR heterodimer transactivates enhancer 1.

引用

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页码：547 / 551

页数：5

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