INTRATHECAL ADMINISTRATION OF NETILMICIN IN GENTAMICIN-RESISTANT VENTRICULITIS

被引：13

作者：

DONAUER, E ^{[1
]}

DRUMM, G ^{[1
]}

MORINGLANE, J ^{[1
]}

OSTERTAG, C ^{[1
]}

KIVELITZ, R ^{[1
]}

机构：

[1] SAARLAND UNIV, NEUROSURG CLIN, D-6650 HOMBURG, FED REP GER

来源：

ACTA NEUROCHIRURGICA | 1987年 / 86卷 / 3-4期

关键词：

D O I：

10.1007/BF01402289

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In ventriculitis caused by Gentamicin-resistant Staphylococcus aureus and Staphylococcus epidermidis, Netilmicin was administered intrathecally to 19 patients under continuous control of the Netilmicin concentration in cerebro-spinal fluid (CSF). This therapy was able to bring these otherwise lethal infections under control, usually within 10 days. Pharmacokinetic studies with different doses have shown that doses of 2 .times. 3 mg are to be recommended in moderately severe cases of ventriculitis, and in most severe infections 3 .times. 3 mg daily intraventricularly for adults. In infants daily intraventricular injections of 2 .times. 0.4-0.5 mg Netilmicin are a sufficient dose to produce an effective antibiotic concentration level.

引用

页码：83 / 88

页数：6

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