PUMILACIDIN, A COMPLEX OF NEW ANTIVIRAL ANTIBIOTICS - PRODUCTION, ISOLATION, CHEMICAL-PROPERTIES, STRUCTURE AND BIOLOGICAL-ACTIVITY

被引：108

作者：

NARUSE, N

TENMYO, O

KOBARU, S

KAMEI, H

MIYAKI, T

KONISHI, M

OKI, T

机构：

[1] Bristol-Myers Research Institute, Ltd., Tokyo Research Center, Tokyo 153, 2-9-3 Shimo-meguro, Meguro-ku

来源：

JOURNAL OF ANTIBIOTICS | 1990年 / 43卷 / 03期

关键词：

D O I：

10.7164/antibiotics.43.267

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

New antibiotic pumilacidins A, B, C, D, E, F and G were isolated from the culture broth of a strain of Bacillus pumilus. They are cyclic acylheptapeptide composed of a β-hydroxy fatty acid, two L-leucine, two D-leucine, L-glutamic acid, L-aspartic acid and L-isoleucine (or L-valine). Pumilacidin components were inhibitory to herpes simplex virus type 1 and H+, K+-ATPase and demonstrated antiulcer activity in rat. © 1990, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.

引用

页码：267 / 280

页数：14

共 13 条

[1]

[Anonymous], 1973, THE GENUS BACILLUS

[2]

Gibbons NE, 1974, BERGEYS MANUAL DETER, P529

[3]

HAKOMORI SI, 1964, J BIOCHEM-TOKYO, V55, P205

[4] ACYLPEPTIDES, THE INHIBITORS OF CYCLIC ADENOSINE-3',5'-MONOPHOSPHATE PHOSPHODIESTERASE .2. AMINO-ACID-SEQUENCE AND LOCATION OF LACTONE LINKAGE [J].