EXPRESSION OF TRANSFORMING GROWTH FACTOR-BETA-1 MESSENGER-RNA IN HUMAN HEPATOCELLULAR-CARCINOMA

被引：19

作者：

ITO, N

KAWATA, S

TAMURA, S

TAKAISHI, K

YABUUCHI, I

MATSUDA, Y

NISHIOKA, M

TARUI, S

机构：

[1] OSAKA UNIV,SCH MED,DEPT INTERNAL MED 2,FUKUSHIMA KU,OSAKA 553,JAPAN

[2] OHTEMAE GEN HOSP,CHUO KU,OSAKA 540,JAPAN

来源：

JAPANESE JOURNAL OF CANCER RESEARCH | 1990年 / 81卷 / 12期

关键词：

TRANSFORMING GROWTH FACTOR-BETA-1; HEPATOCELLULAR CARCINOMA;

D O I：

10.1111/j.1349-7006.1990.tb02678.x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We investigated the expression of transforming growth factor beta-1 (TGF-beta-1) mRNA in tumor tissues surgically removed from ten patients with hepatocellular carcinoma (HCC). All HCC tissues expressed TGF-beta-1 mRNA at different levels, indicating the presence of activated transcription of TGF-beta-1 gene in human HCC tissues in vivo. The level of TGF-beta-1 mRNA expression showed no relationship to main tumor size or plasma alpha-fetoprotein level. Some HCC tissues presenting a relatively low grade of histological differentiation showed the highest levels of TGF-beta-1 mRNA expression.

引用

页码：1202 / 1205

页数：4

共 27 条

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