EFFECT OF THE POTASSIUM CHANNEL OPENER EMD-56431 ON GLOBALLY ISCHEMIC RAT HEARTS

被引：9

作者：

SARGENT, CA ^{[1
]}

DZWONCZYK, S ^{[1
]}

GROVER, GJ ^{[1
]}

机构：

[1] BRISTOL MYERS SQUIBB,PHARMACEUT RES INST,DEPT PHARMACOL,POB 4000,PRINCETON,NJ 08543

来源：

PHARMACOLOGY | 1992年 / 45卷 / 05期

关键词：

MYOCARDIAL ISCHEMIA; POTASSIUM CHANNELS; CORONARY FLOW; CROMAKALIM; EMD-56431;

D O I：

10.1159/000139009

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effect of the ATP-sensitive potassium channel opener EMD 56431 on coronary vasodilation and cardioprotection in isolated rat hearts was investigated. EMD 56431 caused a significant increase in pre-ischemic coronary flow. Time to contracture and reperfusion function were significantly increased at 3, 10 and 30 muM concentrations. LDH release was significantly reduced at 10 and 30 muM concentrations. 1 muM glyburide completely abolished the protective effects found with 10 muM EMD 56431. When given during reperfusion only, 10 muM EMD 56431 showed no cardioprotection. Thus, EMD 56431 appeared to reduce the severity of ischemia/reperfusion injury. The vasorelaxant versus cardioprotective effects for EMD 56431 are similar to other potassium channel openers, such as cromakalim.

引用

页码：260 / 268

页数：9

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