D-FENFLURAMINE, BUT NOT D-NORFENFLURAMINE, USES CALCIUM TO INCREASE EXTRACELLULAR SEROTONIN

被引：11

作者：

DEPARADA, MP ^{[1
]}

PARADA, MA ^{[1
]}

POTHOS, E ^{[1
]}

HOEBEL, BG ^{[1
]}

机构：

[1] PRINCETON UNIV, DEPT PSYCHOL, PRINCETON, NJ 08544 USA

来源：

LIFE SCIENCES | 1995年 / 56卷 / 22期

关键词：

FENFLURAMINE; NORFENFLURAMINE; SEROTONIN; HIPPOCAMPUS; MICRODIALYSIS; CALCIUM;

D O I：

10.1016/0024-3205(95)00168-6

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Microdialysis in the hippocampus of freely moving rats was used to assess extracellular serotonin (5-HT) in response to local infusion of d-fenfluramine and its metabolite d-norfenfluramine with and without local calcium depletion. Verapamil (1 mM) in calcium-free Ringer infused via the microdialysis probe increased extracellular 5-HT and prevented the full increase in extracellular 5-HT normally caused by 1 mM d-fenfluramine. The results suggest d-fenfluramine might act in part as a calcium channel agonist favoring a calcium influx that in turn would trigger the exocytotic process in 5-HT terminals. d-norfenfluramine, on the other hand, was capable of releasing 5-HT, in vivo, in spite of depleted Ca levels.

引用

页码：PL415 / PL420

页数：6

共 24 条

[1] CORRELATION OF PARTITION COEFFICIENTS IN N-HEPTANE-AQUEOUS SYSTEMS WITH BUCCAL ABSORPTION DATA FOR A SERIES OF AMINES AND ACIDS [J].

BECKETT, AH ;

MOFFAT, AC .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1969, S 21 :S144-&

[2] DIFFERENCES BETWEEN D-FENFLURAMINE AND D-NORFENFLURAMINE IN SEROTONIN PRE-SYNAPTIC MECHANISMS [J].

BORRONI, E ;

CECI, A ;

GARATTINI, S ;

MENNINI, T .

JOURNAL OF NEUROCHEMISTRY, 1983, 40 (03) :891-893

[3]

CACCIA S, 1981, European Journal of Drug Metabolism and Pharmacokinetics, V6, P297

[4]

CAMPBELL DB, 1991, REV CONTEMP PHARMACO, V2, P93

[5]

CARBONI E, 1988, VOLTAGE SENSITIVE IO, P171

[6] AMMONIA-INDUCED RELEASE OF NEUROTRANSMITTERS FROM RAT-BRAIN SYNAPTOSOMES - DIFFERENCES BETWEEN THE EFFECTS ON AMINES AND AMINO-ACIDS [J].

ERECINSKA, M ;

PASTUSZKO, A ;

WILSON, DF ;

NELSON, D .

JOURNAL OF NEUROCHEMISTRY, 1987, 49 (04) :1258-1265

[7] THE CONDITIONS OF CA-2+ ENTRY VIA L-TYPE CHANNELS FOR INDUCTION OF SEROTONIN RELEASE FROM RABBIT HIPPOCAMPUS [J].

FEUERSTEIN, TJ ;

NEUSCHWANDER, E ;

SAUERMANN, W ;

LUPP, A .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1991, 198 (01) :37-42

[8] MODULATION OF [H-3] SEROTONIN RELEASE BY DIHYDROPYRIDINES IN SPINAL-CORD SYNAPTOSOMES [J].

GANDHI, VC ;

JONES, DJ .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1990, 187 (02) :271-280

[9] EVIDENCE OF AN EXOCYTOTIC-LIKE RELEASE OF [H-3] 5-HYDROXYTRYPTAMINE INDUCED BY D-FENFLURAMINE IN RAT HIPPOCAMPAL SYNAPTOSOMES [J].

GOBBI, M ;

FRITTOLI, E ;

USLENGHI, A ;

MENNINI, T .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1993, 238 (01) :9-17

[10]

GOBBI M, 1992, N-S ARCH PHARMACOL, V345, P1

← 1 2 3 →