FLOW-INJECTION FLUOROMETRIC ANALYSIS OF SULFAMETHOXAZOLE IN PHARMACEUTICAL PREPARATIONS AND BIOLOGICAL-FLUIDS

被引：9

作者：

ERROZ, CL

VINAS, P

CORDOBA, MH

机构：

[1] Department of Analytical Chemistry, Faculty of Chemistry, University of Murcia

来源：

TALANTA | 1994年 / 41卷 / 12期

关键词：

D O I：

10.1016/0039-9140(94)00203-7

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A fluorimetric procedure for the determination of sulfamethoxazole using flow injection analysis is proposed. A two channel system is optimized for the fluorescent reaction with o-phthaldialdehyde and beta-mercaptoethanol. The detection limit is 0.007 mu g/ml. No fluorescence is generated by the metabolite N-acetylated sulfamethoxazole. The method is applied to the determination of sulfamethoxazole in pharmaceuticals, urine and bovine serum samples without matrix interference problems.

引用

页码：2159 / 2164

页数：6

共 13 条

[1] A SELECTIVE POSTCOLUMN "ORTHO-PHTHALALDEHYDE-DERIVATIZATION SYSTEM FOR THE DETERMINATION OF HISTAMINE IN BIOLOGICAL-MATERIAL BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY [J].