PAROXETINE INCREASES SERUM TRIMIPRAMINE CONCENTRATION - A REPORT OF 2 CASES

被引：15

作者：

LEINONEN, E ^{[1
]}

KOPONEN, HJ ^{[1
]}

LEPOLA, U ^{[1
]}

机构：

[1] MOISIO HOSP,MIKKELI,FINLAND

来源：

HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL | 1995年 / 10卷 / 04期

关键词：

CYTOCHROME P450; DRUG INTERACTION; PAROXETINE; TRIMIPRAMINE;

D O I：

10.1002/hup.470100415

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Paroxetine is a new antidepressant, a selective serotonin reuptake inhibitor (SSRI), which has marked inhibiting effect on microsomal cytochrome P450 enzymes inhuman liver. In this case report we describe two patients whose serum trimipramine and desmethyltrimipramine concentrations increased markedly when paroxetine was added to their drug therapy. We suggest that this was due to the inhibitory effect of paroxetine on the CYP 2D6-mediate metabolism of trimipramine. This interaction may be of clinical importance as both patients had side-effects, such as sedation and orthostatic hypotension,during the simultaneous administration.

引用

页码：345 / 347

页数：3

共 13 条

[1]

American Psychiatric Association, 1987, DIAGNOSTIC STAT MANU, V3rd

[2] A 12-WEEK DOUBLE-BLIND MULTICENTER STUDY OF PAROXETINE AND IMIPRAMINE IN HOSPITALIZED DEPRESSED-PATIENTS [J].