INFLUENCE OF HEXACHLOROCYCLOHEXANE ON PHOSPHOINOSITIDES IN RAT ERYTHROCYTE-MEMBRANES AND BRAIN

被引:9
作者
AGRAWAL, D
SUBRAMONIAM, A
AFAQ, F
机构
[1] Industrial Toxicology Research Centre, Lucknow, 226 001, M.G. Marg
关键词
HEXACHLOROCYCLOHEXANE; PHOSPHOINOSITIDES; ERYTHROCYTE MEMBRANE; CEREBRUM; RAT;
D O I
10.1016/0300-483X(94)02898-5
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Single exposure of rats to hexachlorocyclohexane (100 mg/kg) did not cause any significant change in phosphoinositide levels in rat erythrocyte membrane and cerebrum (fore brain) 2 or 24 h after exposure. However, the phosphoinositide turnover and generation of second messengers from phosphoinositides were increased in the treated erythrocyte membranes as judged from a marked increase in the incorporation of [2-H-3]inositol into phosphoinositides 24 h after the treatment. A significant decrease in phosphatidylinositol (PI), phosphatidylinositol 4-phosphate (PIP) and phosphatidylinositol 4,5-bisphosphate (PIP2) was observed in the erythrocyte membrane and cerebrum of rats repeatedly exposed to the pesticide for 3 or 6 months. This drastic reduction in phosphoinositide levels suggests adverse effects on vital membrane and cell functions modulated by phosphoinositides.
引用
收藏
页码:135 / 140
页数:6
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