SIMPLE NEW METHOD FOR THE SYNTHESIS OF 5-DEAZA-10-OXAFLAVIN, A POTENTIAL ORGANIC OXIDANT

被引：46

作者：

CHEN, X ^{[1
]}

TANAKA, K ^{[1
]}

YONEDA, F ^{[1
]}

机构：

[1] KYOTO UNIV, FAC PHARMACEUT SCI, SAKYO KU, KYOTO 606, JAPAN

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1990年 / 38卷 / 02期

关键词：

5-deaza-10-oxaflavin; 6-chlorouracil; allylic alcohol; barbituric acid; benzylic alcohol; hetero Diels-Alder reaction; hydride transfer; redox reaction;

D O I：

10.1248/cpb.38.307

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Several 5-deaza-10-oxaflavin (2H-chromeno[2,3-d]pyrimidine-2,4(3H)dione) derivatives (1) were prepared in satisfactory yields through new, practical routes. These 5-deaza-10-oxaflavins showed a strong redox property in the oxidation of some alcohols to the corresponding carbonyl compounds under slightly acidic conditions, while they were reduced to the stable 1,5-dihydro derivatives. Participation of a direct hydride transfer from the alcohol was demonstrated by an experiment using deuterium-labeled alcohol. © 1990, The Pharmaceutical Society of Japan. All rights reserved.

引用

页码：307 / 311

页数：5

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