ENZYMATIC GLYCOSPHINGOLIPID SYNTHESIS ON POLYMER SUPPORTS .1. PREPARATION OF MODIFIED NATIVE ACCEPTORS

Two synthetic approaches leading to N-4-carboxymethyl-2-nitrobenzyloxycarbonyl derivatives of model compounds and of glycosylsphingosines are described. The carboxymethyl group can be converted into a hydrazido derivative and the resulting products react with an active ester polymer yielding light-sensitive polymeric products that may subsequently serve as acceptors in glycosyltransferase reactions. © 1990 Glycoconjugate Journal AB.