LEVODOPA-RESPONSIVE PARKINSONISM IN A PATIENT WITH DOWNS-SYNDROME

被引：6

作者：

SINGER, C ^{[1
]}

SANCHEZRAMOS, J ^{[1
]}

WEINER, WJ ^{[1
]}

机构：

[1] UNIV MIAMI,SCH MED,DEPT NEUROL,POB 016960,MIAMI,FL 33101

来源：

EUROPEAN NEUROLOGY | 1990年 / 30卷 / 05期

关键词：

Down’s syndrome; Parkinsonism; Parkinson’s disease; Trisomy; 21;

D O I：

10.1159/000117355

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We report a patient with Down’s syndrome (DS) who developed progressive parkinsonian symptomatology at the age of 43 years. His parkinsonism was responsive to levodopa/carbidopa, but he developed end of dose wearing off. We discuss basal ganglia and dopamine abnormalities in DS and suggest that DS may be associated with parkinsonism. © 1990 S. Karger AG, Basel.

引用

页码：247 / 248

页数：2

共 8 条

[1] SOME EXTRAPYRAMIDAL MOTOR SIGNS IN CASES OF UNDIFFERENTIATED AMENTIA [J].

BURT, AA ;

NAGDEE, KA ;

JAMES, FE .

EUROPEAN NEUROLOGY, 1980, 19 (04) :258-261

[2] THE SUBSTANTIA NIGRA AND VENTRAL TEGMENTAL AREA IN ALZHEIMERS-DISEASE AND DOWNS-SYNDROME [J].

GIBB, WRG ;

MOUNTJOY, CQ ;

MANN, DMA ;

LEES, AJ .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1989, 52 (02) :193-200

[3]

GOODRIGE H, 1987, J NEUROL NEUROSUR PS, V50, P775

[4] DOWNS-SYNDROME, AGING, AND ALZHEIMERS-DISEASE - A CLINICAL REVIEW [J].

LOTT, IT .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1982, 396 (OCT) :15-27

[5] DOPAMINERGIC NEUROTRANSMITTER SYSTEMS IN ALZHEIMERS-DISEASE AND IN DOWNS-SYNDROME AT MIDDLE-AGE [J].

MANN, DMA ;

YATES, PO ;

MARCYNIUK, B .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1987, 50 (03) :341-344

[6] BASAL GANGLIA CALCIFICATION AND PSYCHOSIS IN DOWNS-SYNDROME [J].

THASE, ME .

POSTGRADUATE MEDICAL JOURNAL, 1984, 60 (700) :137-139

[7] BASAL GANGLIA CALCIFICATION (BGC) IN DOWNS-SYNDROME (DS) - ANOTHER MANIFESTATION OF PREMATURE AGING [J].

WISNIEWSKI, KE ;

FRENCH, JH ;

ROSEN, JF ;

KOZLOWSKI, PB ;

TENNER, M ;

WISNIEWSKI, HM .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1982, 396 (OCT) :179-189

[8] CATECHOLAMINES AND CHOLINERGIC ENZYMES IN PRESENILE AND SENILE ALZHEIMER-TYPE DEMENTIA AND DOWNS-SYNDROME [J].

YATES, CM ;

SIMPSON, J ;

GORDON, A ;

MALONEY, AFJ ;

ALLISON, Y ;

RITCHIE, IM ;

URQUHART, A .

BRAIN RESEARCH, 1983, 280 (01) :119-126

← 1 →