ANTIBODIES TO A RECOMBINANT GLUTAMATE-RICH PLASMODIUM-FALCIPARUM PROTEIN - EVIDENCE FOR PROTECTION OF INDIVIDUALS LIVING IN A HOLOENDEMIC AREA OF LIBERIA

被引:34
作者
HOGH, B
PETERSEN, E
DZIEGIEL, M
DAVID, K
HANSON, A
BORRE, M
HOLM, A
VUUST, J
JEPSEN, S
机构
[1] LIBERIAN INST BIOMED RES,ROBERTSFIELD,LIBERIA
[2] ROYAL VET & AGR UNIV,INST CHEM,COPENHAGEN,DENMARK
关键词
D O I
10.4269/ajtmh.1992.46.307
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
A Plasmodium falciparum antigen gene coding for a 220-kD glutamate-rich protein (GLURP) has been cloned, and the 783 C-terminal amino acids of this protein (GLURP489-1271) have been expressed as a beta-galactosidase fusion protein in Escherichia coli. The encoded 783 amino acid residues contain two areas of repeated amino acid sequences. Antibodies against recombinant GLURP489-1271, as well as against a synthetic peptide corresponding to GLURP899-916, and against a synthetic peptide representing the major glutamate rich repeat sequence from the P. falciparum ring erythrocyte surface antigen (Pf155/RESA) (EENV)6 were examined in 423 individuals (age range 30 days-78 years) living in a malaria holoendemic area of Liberia. In the 5-9-year-old age group, subjects with anti-GLURP489-1271 antibody concentrations greater than the mean value of the group had lower parasite densities than those with low antibody concentrations (P = 0.0151). High levels of anti-GLURP899-916 antibodies did not correlate with low parasite densities. However, high levels of anti-(EENV)6 antibodies were associated with significantly lower parasite densities in the 2-4-year-old age group (P = 0.0189). There was no correlation between the anti-GLURP489-1271 and anti-(EENV)6 antibody responses. The data provide indirect evidence for a protective role of antibodies reacting with recombinant GLURP489-1271 as well as with the synthetic peptide (EENV)6 from the Pf155/RESA.
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页码:307 / 313
页数:7
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