CHARACTERIZATION AND PHARMACOLOGICAL SENSITIVITY OF ANTIGEN ARTHRITIS INDUCED BY METHYLATED BOVINE SERUM-ALBUMIN IN THE RAT

被引：47

作者：

GRIFFITHS, RJ

机构：

[1] Department of Pharmacology, Fisons plc, Research and Development Laboratories, Loughborough, LE11 ORH, Bakewell Road

来源：

AGENTS AND ACTIONS | 1992年 / 35卷 / 1-2期

关键词：

D O I：

10.1007/BF01990957

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The optimum conditions for the induction of antigen-induced arthritis in the rat have been studied. Two immunisations with methylated bovine serum albumin (mBSA) (0.5 mg) in Freund's complete adjuvant (FCA) containing 0.375 mg Mycobacterium tuberculosis followed by an intra-articular injection of mBSA (0.5 mg) led to the production of a chronic, erosive arthritis. The development of the arthritis was associated with the appearance of T lymphocytes and other inflammatory cells in the synovium. Male and female animals were equally susceptible to the disease. Prednisolone, indomethacin and methotrexate inhibited the development of the arthritis but ibuprofen and D-penicillamine were without any significant effect.

引用

页码：88 / 95

页数：8

共 15 条

[1] MODELS OF ARTHRITIS AND THE SEARCH FOR ANTI-ARTHRITIC DRUGS [J].

BILLINGHAM, MEJ .

PHARMACOLOGY & THERAPEUTICS, 1983, 21 (03) :389-428

[2] ROLE OF PROSTAGLANDINS IN RABBIT MONOARTICULAR ARTHRITIS [J].

BLACKHAM, A ;

FARMER, JB ;

RADZIWONIK, H ;

WESTWICK, J .

BRITISH JOURNAL OF PHARMACOLOGY, 1974, 51 (01) :35-44

[3]

BRACKERTZ D, 1977, J IMMUNOL, V118, P1639

[4] ANTIGEN-INDUCED ARTHRITIS IN MICE .1. INDUCTION OF ARTHRITIS IN VARIOUS STRAINS OF MICE [J].

BRACKERTZ, D ;

MITCHELL, GF ;

MACKAY, IR .

ARTHRITIS AND RHEUMATISM, 1977, 20 (03) :841-850

[5]

BRACKERTZ D, J IMMUNOL, V118, P1645

[6] MACROPHAGES AND DENDRITIC CELLS IN ANTIGEN-INDUCED ARTHRITIS - AN IMMUNOHISTOCHEMICAL STUDY USING CRYOSTAT SECTIONS OF THE WHOLE KNEE-JOINT OF RAT [J].

DIJKSTRA, CD ;

DOPP, EA ;

VOGELS, IMC ;

VANNOORDEN, CJF .

SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 1987, 26 (05) :513-523

[7]

DUMONDE DC, 1962, BRIT J EXP PATHOL, V43, P373

[8] PERSISTENCE OF ANTIGEN IN NONARTHRITIC JOINTS [J].

FOX, A ;

GLYNN, LE .

ANNALS OF THE RHEUMATIC DISEASES, 1975, 34 (05) :431-437

[9] PHARMACOLOGICAL STUDIES OF ANTIGEN-INDUCED ARTHRITIS IN BALB/C MICE .2. THE EFFECTS OF 2ND-LINE ANTIRHEUMATIC DRUGS AND CYTOTOXIC AGENTS ON THE HISTOPATHOLOGICAL CHANGES [J].

HUNNEYBALL, IM ;

CROSSLEY, MJ ;

SPOWAGE, M .

AGENTS AND ACTIONS, 1986, 18 (3-4) :394-400

[10] PHARMACOLOGICAL STUDIES OF ANTIGEN-INDUCED ARTHRITIS IN BALB/C MICE .1. CHARACTERIZATION OF THE ARTHRITIS AND THE EFFECTS OF STEROIDAL AND NONSTEROIDAL ANTIINFLAMMATORY AGENTS [J].

HUNNEYBALL, IM ;

CROSSLEY, MJ ;

SPOWAGE, M .

AGENTS AND ACTIONS, 1986, 18 (3-4) :384-393

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