COMPLEX PATTERNS OF [I-125] OMEGA-CONOTOXIN GVIA BINDING-SITE EXPRESSION DURING POSTNATAL RAT-BRAIN DEVELOPMENT

被引：24

作者：

FILLOUX, F

SCHAPPER, A

NAISBITT, SR

OLIVERA, BM

MCINTOSH, JM

机构：

[1] UNIV UTAH,DEPT NEUROL,SALT LAKE CITY,UT 84132

[2] UNIV UTAH,DEPT PSYCHIAT,SALT LAKE CITY,UT 84132

[3] UNIV UTAH,DEPT BIOL,SALT LAKE CITY,UT 84132

[4] UNIV UTAH,DEPT PEDIAT,SALT LAKE CITY,UT 84132

来源：

DEVELOPMENTAL BRAIN RESEARCH | 1994年 / 78卷 / 01期

基金：

美国国家卫生研究院;

关键词：

I-125] OMEGA-CONOTOXIN GVIA; N-TYPE CALCIUM CHANNEL; AUTORADIOGRAPHY; RAT BRAIN DEVELOPMENT;

D O I：

10.1016/0165-3806(94)90017-5

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In the mature CNS, N-type calcium channels regulate neurotransmitter release. The role of these channels in developing brain is less clear. Study of [I-125]omega-conotoxin GVIA binding sites in developing rat brain using autoradiography reveals that putative N-type channels appear and disappear in complex temporal-spatial profiles including: (1) gradual increase to adult levels (cerebral cortex); (2) substructure differentiation (cerebellum); (3) transient expression (pens); and, (4) selective depletion (medulla). Transient expression of N-type calcium channels may influence specific neurodevelopmental processes.

引用

页码：131 / 136

页数：6

共 34 条

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