ADMINISTRATION OF AMYLOID BETA-PEPTIDES INTO THE MEDIAL SEPTUM OF RATS DECREASES ACETYLCHOLINE-RELEASE FROM HIPPOCAMPUS IN-VIVO

被引：78

作者：

ABE, E

CASAMENTI, F

GIOVANNELLI, L

SCALI, C

PEPEU, G

机构：

[1] UNIV FLORENCE,DEPT PRECLIN & CLIN PHARMACOL,I-50134 FLORENCE,ITALY

[2] IWATE MED UNIV,SCH DENT,DEPT PHARMACOL,MORIOKA,IWATE 020,JAPAN

来源：

BRAIN RESEARCH | 1994年 / 636卷 / 01期

关键词：

ALZHEIMERS DISEASE; AMYLOID BETA-PEPTIDES; ACETYLCHOLINE RELEASE; MICRODIALYSIS; SEPTOHIPPOCAMPAL PATHWAY;

D O I：

10.1016/0006-8993(94)90193-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The septum of male Wistar rats was injected with synthetic beta-amyloid fragments, beta(12-28), beta(25-35) and beta(1-40), and hippocampal acetylcholine (ACh) release was evaluated by transversal microdialysis. A marked decrease in basal and K+-evoked ACh release was found 7 or 21 days after injection of 5 nmol of beta(12-28) and beta(25-35), or 3 nmol of beta(1-40), respectively. These data indicate that septal injection of beta-amyloid peptides causes hypofunction of the septo-hippocampal cholinergic system.

引用

页码：162 / 164

页数：3

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