REDUCED BREAST-CANCER RISK AFTER REMARRIAGE - EVIDENCE OF GENETIC IMMUNE PROTECTION

被引：7

作者：

JANERICH, DT

THOMPSON, WD

机构：

[1] Department of Medicine, University of Utah School of Medicine, Salt Lake City, UT

[2] Foundation for Blood Research, Scarborough, ME

[3] Department of Applied Medical Sciences, University of Southern Maine, Portland, ME

来源：

EPIDEMIOLOGY | 1995年 / 6卷 / 03期

关键词：

BREAST NEOPLASMS; FETAL GENETICS; IMMUNOLOGY; REMARRIAGE;

D O I：

10.1097/00001648-199505000-00011

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Several reproductive factors have been found to be associated with breast cancer. Based on an immunologic rather than strictly hormonal interpretation of these observations, we hypothesised that, beyond the observed associations relating to pregnancy per se, multiple marriages would be found to protect women against breast cancer. We obtained cases and controls from linked records from the Utah Cancer Registry and genealogic records. A total of 2,414 women with newly diagnosed breast cancer and 9,138 individually matched controls were included. The unadjusted odds ratio for each marriage after the first was 0.81 [95% confidence interval (CI) = 0.68-0.97]. After adjustment for major reproductive factors, multiple marriages were still found to reduce the risk of breast cancer (odds ratio = 0.86; 95% CI = 0.72-1.03), The findings are consistent with the operation of an immunologic mechanism in the etiology of breast cancer and suggest that the gene/antigen responsible for this effect is quite common in males. Further empirical evaluation of the fetal antigen hypothesis seems warranted.

引用

页码：254 / 257

页数：4

共 33 条

[1]

Kelsey J.L., Gammon M.D., John E.M., Reproductive factors and breast cancer, Epidemiol Rev, 15, pp. 36-47, (1993)

[2]

MacMahon B., Cole P., Lin T.M., Lowe C.R., Mirra A.P., Ravnihar B., Salber E.J., Valaoras V.G., Yuasa S., Age at first birth and breast cancer risk, Bull WHO, 43, pp. 209-221, (1970)

[3]

Layde P.M., Webster L.A., Baughman A.L., Wingo P.A., Rubin G.L., Ory H.W., And The Cancer and Steroid Hormone Study Group. The independent associations of parity, age at first full term pregnancy, and duration of breastfeeding with the risk of breast cancer, J Clin Epidemiol, 42, pp. 963-973, (1989)

[4]

Yuan J.-M., Yu M.C., Ross R.K., Gao Y.T., Henderson B.E., Risk factors for breast cancer in Chinese women in Shanghai, Cancer Res, 48, pp. 1949-1953, (1988)

[5]

Negri E., La Vecchia C., Duffy S.W., Bruin P., Parazzini F., Day N.E., Age at first and second births and breast cancer risk in biparous women, Int J Cancer, 45, pp. 428-430, (1990)

[6]

Negri E., La Vecchia C., Bruzzi P., Dardanoni G., Decarli A., Palli D., Parazzini F., Rosselli del Turco M., Risk factors for breast cancer: Pooled results from three Italian case-control studies, Am J Epidemiol, 128, pp. 1207-1215, (1988)

[7]

Brinton L.A., Hoover R., Fraumeni J.F., Reproductive factors in the aetiology of breast cancer, Br J Cancer, 47, pp. 757-762, (1983)

[8]

Kvale G., Heuch I., Eide G.E., A prospective study of reproductive factors and breast cancer. I. Parity, Am J Epidemiol, 126, pp. 831-841, (1987)

[9]

Lund E., Number of children and death from hormone-dependent cancers, Int J Cancer, 46, pp. 998-1000, (1990)

[10]

Brinton L.A., Melton L.J., Malkasian G.D., Bond A., Hoover R., Cancer risk after evaluation for infertility, Am J Epidemiol, 129, pp. 712-722, (1989)

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