THE DEVELOPMENT OF ORAL VACCINES AGAINST PARASITIC DISEASES UTILIZING LIVE ATTENUATED SALMONELLA

被引：29

作者：

CHATFIELD, SN ^{[1
]}

ROBERTS, M ^{[1
]}

DOUGAN, G ^{[1
]}

HORMAECHE, C ^{[1
]}

KHAN, CMA ^{[1
]}

机构：

[1] UNIV NEWCASTLE UPON TYNE,SCH MED,DEPT MICROBIOL,NEWCASTLE TYNE NE2 4HH,TYNE & WEAR,ENGLAND

来源：

PARASITOLOGY | 1995年 / 110卷

关键词：

LIVE ATTENUATED SALMONELLA; ORAL VACCINES; SCHISTOSOMIASIS;

D O I：

10.1017/S0031182000001451

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Genetically defined, live attenuated Salmollella vaccines are proving useful both as oral vaccines against salmonellosis and for the development of multivalent vaccines based on the expression of heterologous antigens in such strains. Several candidate attenuated S. typhi strains are at present being evaluated as new single dose oral typhoid vaccines in human volunteers. The emergence of such a vaccine will facilitate the development of multivalent vaccines for humans. Many antigens from different infectious organisms have been expressed in attenuated Salmonella. A focus of this work has been on developing vaccines against parasitic diseases. This review will summarize the efforts that have been made in this area.

引用

页码：S17 / S24

页数：8

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