INVESTIGATION OF PH-SENSITIVE DRUG-DELIVERY SYSTEM OF CHITOSAN/GELATIN HYBRID POLYMER NETWORK

被引：75

作者：

YAO, KD

YIN, YJ

XU, MX

WANG, YF

机构：

[1] Research Institute of Polymeric Materials, Tianjin University, Tianjin

来源：

POLYMER INTERNATIONAL | 1995年 / 38卷 / 01期

关键词：

DRUG RELEASE; HYBRID POLYMER NETWORK; CHITOSAN GELATIN; PH-SENSITIVE GEL; SWELLING;

D O I：

10.1002/pi.1995.210380110

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

A novel hydrogel based on a crosslinked chitosan/gelatin with glutaraldehyde hybrid polymer network was prepared. The gel swells in acidic medium and deswells in alkaline medium. A comparative study of the pH-dependent release of levamisole, cimetidine and chloramphenicol was carried out.

引用

页码：77 / 82

页数：6

共 21 条

[1] Hoffman A.S., Afrassiaki A., Dong L.C., J. Controlled Release, 4, (1986)
[2] Bae Y.H., Okano T., Hsu R., Kim S.W., Die Makromolekulare Chemie, Rapid Communications, 8, (1987)
[3] Seigel R.A., Firestone B.A., Macromolecules, 21, (1988)
[4] Seigel R.A., Falamarizian M., Firestone B.A., Moxley B.C., pH-Controlled release from hydrophobic/polyelectrolyte copolymer hydrogels, Journal of Controlled Release, 8, (1988)
[5] Ishihara K., Hamad N., Kato S., Shinohara I., J. Polym. Sci., Polym. Chem., 22, (1984)
[6] Suzuki A., Tanaka T., Nature, 346, (1990)
[7] Tanaka T., Nishio I., Sun S., Ueno S., Science, 218, (1982)
[8] Yao K.D., Sun Sh., Polym. Bull., 28, (1992)
[9] Kwon I.C., Bae Y.H., Okano T., Bemer B., Kim S.W., Stimuli sensitive polymers for drug delivery systems, Makromolekulare Chemie. Macromolecular Symposia, 33, (1990)
[10] Eisenberg S.R., Grodzinsky A.J., J. Membrane Sci., 19, (1984)

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