THE ESSENTIAL ROLE OF ENDOGENOUS IFN ALPHA/BETA IN THE ANTIMETASTATIC ACTION OF SENSITIZED T-LYMPHOCYTES IN MICE INJECTED WITH FRIEND-ERYTHROLEUKEMIA CELLS

被引：23

作者：

GRESSER, I

MAURY, C

KAIDO, T

BANDU, MT

TOVEY, MG

MAUNOURY, MT

FANTUZZI, L

GESSANI, S

GRECO, G

BELARDELLI, F

机构：

[1] INST GUSTAVE ROUSSY,GENET ONCOL LAB,VILLEJUIF,FRANCE

[2] IST SUPER SANITA,VIROL LAB,I-00161 ROME,ITALY

来源：

INTERNATIONAL JOURNAL OF CANCER | 1995年 / 63卷 / 05期

关键词：

D O I：

10.1002/ijc.2910630520

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Adoptive transfer of splenic T lymphocytes from DBA/2 mice immunized against Friend erythroleukemia cells (FLC) inhibited the development of visceral metastases and increased the survival time of DBA/2 mice challenged i.v. with parental FLC 24 hr to 2 months later. Immune spleen cells were ineffective in mice pre-treated with potent neutralizing antibody to mouse IFN alpha/beta (but not to IFN gamma), demonstrating the essential participation of endogenous IFN alpha/beta in the inhibitory action of immune T lymphocytes against FLC metastases. These findings suggest that the reported inability of immune T lymphocytes to exert an anti-FLC effect in immunodeficient DBA/2 mutant beige (bg/bg) mice (unless these mice had also been treated with IFN alpha/beta), may have been due to lower levels of endogenous IFN alpha/beta in DBA/2 bg/bg mice than in normal DBA/2+/bg mice. Experimental results in support of this hypothesis are presented. (C) 1995 Wiley-Liss, Inc.

引用

页码：726 / 731

页数：6

共 28 条

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