DIFFERENTIAL CHARACTERISTICS OF THE THORACIC AND ABDOMINAL MAMMARY-GLANDS FROM MICE

被引：10

作者：

BOLANDER, FF

机构：

[1] Department of Biological Sciences, University of South Carolina, Columbia

来源：

EXPERIMENTAL CELL RESEARCH | 1990年 / 189卷 / 01期

关键词：

D O I：

10.1016/0014-4827(90)90266-D

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The anatomical and physiological characteristics of thoracic and abdominal mammary glands were investigated in order to understand why the incidence of mammary tumors is higher in the former. Epithelium in explants from both sets of glands required DNA synthesis, insulin, cortisol, and prolactin for full differentiation as measured by α-lactalbumin accumulation. The temporal pattern and magnitude of response were the same with respect to both DNA synthesis and differentiation; however, the epithelium in explants from the thoracic glands required concentrations of hormones for α-lactalbumin accumulation only one-half to one-third those from abdominal glands. Tumor distribution did not appear to correlate with mammary gland histology, size, or epithelial content. © 1990.

引用

页码：142 / 144

页数：3

共 18 条

[1] STIMULATION OF LACTOSE SYNTHETASE-ACTIVITY AND CASEIN SYNTHESIS IN MOUSE MAMMARY EXPLANTS BY ESTRADIOL [J].