ACTIVATION OF HIPPOCAMPAL METABOTROPIC EXCITATORY AMINO-ACID RECEPTORS LEADS TO SEIZURES AND NEURONAL DAMAGE

被引：175

作者：

SACAAN, AI ^{[1
]}

SCHOEPP, DD ^{[1
]}

机构：

[1] ELI LILLY & CO,LILLY RES LAB,CENT NERVOUS SYST RES,LILLY CORP CTR,INDIANAPOLIS,IN 46285

来源：

NEUROSCIENCE LETTERS | 1992年 / 139卷 / 01期

关键词：

EXCITATORY AMINO ACID; GLUTAMATE; METABOTROPIC; NEUROTOXICITY; HIPPOCAMPUS; SEIZURE; 1-AMINOCYCLOPENTANE-1,3-DICARBOXYLIC ACID; NMDA;

D O I：

10.1016/0304-3940(92)90862-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A role for ionotropic (NMDA, AMPA, and kainate) excitatory amino acid (EAA) receptors in seizure and seizure-related brain damage is well documented. To study the possible role of metabotropic (G-protein linked) EAA receptors in this regard, a highly selective metabotropic EAA agonist was injected into the hippocampus of halothane-anesthetized rats. This resulted in delayed-onset seizures and selective hippocampal neuronal damage that was indirectly mediated by NMDA receptors. This provides direct evidence for a novel role of metabotropic EAA receptors in the etiology of seizures and neuronal damage.

引用

页码：77 / 82

页数：6

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