IS APOPTOSIS MEDIATED BY REACTIVE OXYGEN SPECIES

被引：173

作者：

SARAFIAN, TA

BREDESEN, DE

机构：

[1] UNIV CALIF LOS ANGELES,SCH MED,REED NEUROL RES CTR,DEPT NEUROL,LOS ANGELES,CA 90024

[2] UNIV CALIF LOS ANGELES,DEPT PATHOL,LOS ANGELES,CA 90024

[3] UNIV CALIF LOS ANGELES,BRAIN RES INST,LOS ANGELES,CA 90024

[4] UNIV CALIF LOS ANGELES,INST MOLEC BIOL,LOS ANGELES,CA 90024

来源：

FREE RADICAL RESEARCH | 1994年 / 21卷 / 01期

关键词：

APOPTOSIS; PROGRAMMED CELL DEATH; NECROSIS; BCL-2; ANTI-APOPTOTIC GENE; INTERNUCLEOSOMAL DNA FRAGMENTATION;

D O I：

10.3109/10715769409056549

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Apoptosis is a common mode of programmed cell death occurring during development as well as in many pathological conditions, in which the cell plays an active role in its own demise. Although the morphological and biochemical hallmarks of apoptosis are conserved across phyla and cell type, the mechanism(s) of apoptosis is unknown. However, data recently published demonstrate that expression of the anti-apoptotic gene bcl-2 decreases the net cellular generation of reactive oxygen species, and that reactive oxygen species serve as mediators of apoptosis in at least some cases.

引用

页码：1 / 8

页数：8

共 52 条

[1] REDOX REGULATION OF FOS AND JUN DNA-BINDING ACTIVITY INVITRO [J].