SYNTHESIS OF A 2-BENZAZEPINE ANALOG OF A POTENT, NONPEPTIDE GPIIB/IIIA ANTAGONIST

被引：11

作者：

MILLER, WH ^{[1
]}

NEWLANDER, KA ^{[1
]}

EGGLESTON, DS ^{[1
]}

HALTIWANGER, RC ^{[1
]}

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT, DEPT PHYS & STRUCT CHEM, KING OF PRUSSIA, PA 19406 USA

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 03期

关键词：

D O I：

10.1016/0040-4039(94)02273-E

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The preparation of the 2-benzazepine derivative 3 as an analog of the potent, nonpeptide GPIIb/IIIa antagonist 2 is reported. The synthetic route employs as key steps a Heck arylation of dimethyl itaconate and a selective cyclization to form the aryl-fused seven-membered ring.

引用

页码：373 / 376

页数：4

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