DOPA RESISTANCE IN MULTIPLE-SYSTEM ATROPHY - LOSS OF POSTSYNAPTIC D2 RECEPTORS

被引:48
作者
CHURCHYARD, A
DONNAN, GA
HUGHES, A
HOWELLS, DW
WOODHOUSE, D
WONG, JYF
KALNINS, RM
MENDELSOHN, FAO
PAXINOS, G
机构
[1] AUSTIN HOSP,DEPT NEUROL,STUDLEY RD,HEIDELBERG,VIC 3084,AUSTRALIA
[2] AUSTIN HOSP,DEPT MED,HEIDELBERG,VIC 3084,AUSTRALIA
[3] AUSTIN HOSP,DEPT PATHOL,HEIDELBERG,VIC 3084,AUSTRALIA
[4] REPATRIAT GEN HOSP,DEPT NEUROL,HEIDELBERG,VIC 3077,AUSTRALIA
[5] UNIV NEW S WALES,SCH PSYCHOL,KENSINGTON,NSW 2033,AUSTRALIA
关键词
D O I
10.1002/ana.410340219
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Postmortem autoradiography was used to explore the mechanisms underlying L-dopa resistance in 2 patients with multiple-system atrophy. Indices of striatal presynaptic dopamine terminal loss and dopamine (D1 and D2) receptors were provided by H-3-mazindol, H-3-SCH 23390, and I-125-sulpiride binding. Neuronal loss, gliosis, and loss of postsynaptic D2 receptors preferentially involved the middle and posterior of the putamen, that region of the striatum most intimately involved in motor function. Loss of D1 receptors in the same area occurred in only 1 patient. These findings suggest that in multiple-system atrophy, resistance to L-dopa is due to a loss of putamental D2 receptors. The differential effects on D1 and D2 receptors in 1 patient implies that different subpopulations of striatal neurons were selectively involved.
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页码:219 / 226
页数:8
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