A TUMOR-NECROSIS-FACTOR-ALPHA POLYMORPHISM IS NOT ASSOCIATED WITH RHEUMATOID-ARTHRITIS

被引：61

作者：

WILSON, AG ^{[1
]}

DEVRIES, N ^{[1
]}

VANDEPUTTE, LBA ^{[1
]}

DUFF, GW ^{[1
]}

机构：

[1] UNIV NIJMEGEN HOSP,DEPT INTERNAL MED,DIV RHEUMATOL,6500 HB NIJMEGEN,NETHERLANDS

来源：

ANNALS OF THE RHEUMATIC DISEASES | 1995年 / 54卷 / 07期

关键词：

D O I：

10.1136/ard.54.7.601

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective-To determine whether a polymorphism within the tumour necrosis factor alpha (TNF alpha) gene is associated with susceptibility to, or severity of, rheumatoid arthritis (RA). Methods-Consecutive patients with recent onset RA were enrolled in a prospective trial. DNA was collected, disease activity was measured at presentation, and radiographic progression at three years was assessed. Typing of TNF alpha was by polymerase chain reaction and single stranded conformation polymorphism analysis. Results-No association of TNF alpha alleles and susceptibility to, or severity of, RA was demonstrated. Conclusions-These results indicate that this TNF alpha polymorphism does not play a part in the genetic background of RA.

引用

页码：601 / 603

页数：3

共 15 条

[1] THE AMERICAN-RHEUMATISM-ASSOCIATION 1987 REVISED CRITERIA FOR THE CLASSIFICATION OF RHEUMATOID-ARTHRITIS [J].

ARNETT, FC ;

EDWORTHY, SM ;

BLOCH, DA ;

MCSHANE, DJ ;

FRIES, JF ;

COOPER, NS ;

HEALEY, LA ;

KAPLAN, SR ;

LIANG, MH ;

LUTHRA, HS ;

MEDSGER, TA ;

MITCHELL, DM ;

NEUSTADT, DH ;

PINALS, RS ;

SCHALLER, JG ;

SHARP, JT ;

WILDER, RL ;

HUNDER, GG .

ARTHRITIS AND RHEUMATISM, 1988, 31 (03) :315-324

[2] A T-CELL RECEPTOR BETA-CHAIN VARIABLE REGION POLYMORPHISM ASSOCIATED WITH RADIOGRAPHIC PROGRESSION IN RHEUMATOID-ARTHRITIS [J].

DEVRIES, N ;

PRINSEN, CFM ;

MENSINK, EBJM ;

VANRIEL, PLCM ;

VANTHOF, MA ;

VANDEPUTTE, LBA .

ANNALS OF THE RHEUMATIC DISEASES, 1993, 52 (05) :327-331

[3] TUMOR NECROSIS FACTOR IN SYNOVIAL EXUDATES [J].

DIGIOVINE, FS ;

NUKI, G ;

DUFF, GW .

ANNALS OF THE RHEUMATIC DISEASES, 1988, 47 (09) :768-772

[4]

ELLIOTT MJ, 1993, ARTHRITIS RHEUM, V36, P1681, DOI 10.1002/art.23362

[5] HUMAN TUMOR-NECROSIS-FACTOR-ALPHA GENE-REGULATION BY VIRUS AND LIPOPOLYSACCHARIDE [J].

GOLDFELD, AE ;

DOYLE, C ;

MANIATIS, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (24) :9769-9773

[6] THE SHARED EPITOPE HYPOTHESIS - AN APPROACH TO UNDERSTANDING THE MOLECULAR-GENETICS OF SUSCEPTIBILITY TO RHEUMATOID-ARTHRITIS [J].

GREGERSEN, PK ;

SILVER, J ;

WINCHESTER, RJ .

ARTHRITIS AND RHEUMATISM, 1987, 30 (11) :1205-1213

[7] HERITABLE MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-II-ASSOCIATED DIFFERENCES IN PRODUCTION OF TUMOR NECROSIS FACTOR-ALPHA - RELEVANCE TO GENETIC PREDISPOSITION TO SYSTEMIC LUPUS-ERYTHEMATOSUS [J].

JACOB, CO ;

FRONEK, Z ;

LEWIS, GD ;

KOO, M ;

HANSEN, JA ;

MCDEVITT, HO .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (03) :1233-1237

[8] TRANSGENIC MICE EXPRESSING HUMAN TUMOR-NECROSIS-FACTOR - A PREDICTIVE GENETIC MODEL OF ARTHRITIS [J].

KEFFER, J ;

PROBERT, L ;

CAZLARIS, H ;

GEORGOPOULOS, S ;

KASLARIS, E ;

KIOUSSIS, D ;

KOLLIAS, G .

EMBO JOURNAL, 1991, 10 (13) :4025-4031

[9] HLA GENES ASSOCIATED WITH RHEUMATOID-ARTHRITIS - IDENTIFICATION OF SUSCEPTIBILITY ALLELES USING SPECIFIC OLIGONUCLEOTIDE PROBES [J].

NEPOM, GT ;

BYERS, P ;

SEYFRIED, C ;

HEALEY, LA ;

WILSKE, KR ;

STAGE, D ;

NEPOM, BS .

ARTHRITIS AND RHEUMATISM, 1989, 32 (01) :15-21

[10]

SALMON M, 1993, BRIT J RHEUMATOL, V32, P628

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