ASSEMBLY OF ALZHEIMER-LIKE FILAMENTS FROM FULL-LENGTH TAU-PROTEIN

被引：137

作者：

CROWTHER, RA

OLESEN, OF

SMITH, MJ

JAKES, R

GOEDERT, M

机构：

[1] Medical Research Council, Laboratory of Molecular Biology, Cambridge, CB2 2QH, Hills Road

来源：

FEBS LETTERS | 1994年 / 337卷 / 02期

关键词：

ALZHEIMERS DISEASE; MICROTUBULE-ASSOCIATED PROTEIN TAU; PAIRED HELICAL FILAMENT; HYPER-PHOSPHORYLATION;

D O I：

10.1016/0014-5793(94)80260-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The principal fibrous component of neurofibrillary pathology in Alzheimer's disease, the paired helical filament, is formed from hyperphosphorylated microtubule-associated protein tau. Here we show that recombinant tan protein either in a non-phosphorylated state or following phosphorylation with brain extract can be assembled in vitro into filaments resembling those seen in Alzheimer's disease.

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页码：135 / 138

页数：4

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