A P2X PURINOCEPTOR EXPRESSED BY A SUBSET OF SENSORY NEURONS

被引：901

作者：

CHEN, CC ^{[1
]}

AKOPIAN, AN ^{[1
]}

SIVILOTTI, L ^{[1
]}

COLQUHOUN, D ^{[1
]}

BURNSTOCK, G ^{[1
]}

WOOD, JN ^{[1
]}

机构：

[1] UNIV LONDON UNIV COLL,DEPT PHARMACOL,LONDON WC1E 6BT,ENGLAND

来源：

NATURE | 1995年 / 377卷 / 6548期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/377428a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

ATP is known to depolarize sensory neurons, and may play a role in nociceptor activation when released from damaged tissue(1-10). Here we report the molecular cloning and characterization of a new member of the P2X receptor family(3,11,12), P2X(3), expressed by these cells, The channel transcript was present in a subset of rat dorsal-root-ganglion sensory neurons, some of which express nociceptor-associated markers; it was absent in other tissues that were tested, including sympathetic, enteric and central nervous system neurons. Moreover, when expressed in Xenopus oocytes, the channel showed an ATP-dependent cation flux, P2X(3) is the only ligand-gated channel known to be expressed exclusively by a subset of sensory neurons. The remarkable selectivity of expression of the channel coupled with its sensory neuron-like pharmacology suggests that this channel may transduce ATP-evoked nociceptor activation.

引用

页码：428 / 431

页数：4

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