EVIDENCE FOR IMPAIRED T-CELL DNA METHYLATION IN SYSTEMIC LUPUS-ERYTHEMATOSUS AND RHEUMATOID-ARTHRITIS

被引：441

作者：

RICHARDSON, B

SCHEINBART, L

STRAHLER, J

GROSS, L

HANASH, S

JOHNSON, M

机构：

[1] UNIV MICHIGAN,DEPT PEDIAT,ANN ARBOR,MI 48109

[2] VET ADM MED CTR,ANN ARBOR,MI 48105

来源：

ARTHRITIS AND RHEUMATISM | 1990年 / 33卷 / 11期

关键词：

D O I：

10.1002/art.1780331109

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Procainamide and hydralazine inhibit T cell DNA methylation and induce autoreactivity in cloned CD4+ T cells. These drugs also induce an autoimmune syndrome, suggesting a possible relationship between DNA hypomethylation, T cell autoreactivity, and certain autoimmune diseases. To test this relationship, DNA methylation was studied in T cells from patients with rheumatoid arthritis and patients with systemic lupus erythematosus, and was found to be impaired. These results support a relationship between DNA hypomethylation and some forms of autoimmune disease. Copyright © 1990 American College of Rheumatology

引用

页码：1665 / 1673

页数：9

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