THROMBOXANE-A2 PROSTAGLANDIN-H2 RECEPTORS - CHARACTERIZATION AND ANTAGONISM

被引：23

作者：

MORINELLI, TA ^{[1
]}

HALUSHKA, PV ^{[1
]}

机构：

[1] MED UNIV S CAROLINA, DEPT MED, CHARLESTON, SC 29425 USA

来源：

TRENDS IN CARDIOVASCULAR MEDICINE | 1991年 / 1卷 / 04期

关键词：

D O I：

10.1016/1050-1738(91)90021-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Thromboxane A2 (TXA2) is a potent vasoconstrictor and platelet aggregator whose synthesis is increased in a variety of cardiovascular diseases. TXA2 receptor antagonists have been used to (a) establish a pathophysiologic role for TXA2 in a variety of cardiovascular diseases, (b) subtype platelet and vascular receptors, (c) elucidate structural characteristics of the receptor, and (d) aid in its purification. However, much still remains to be learned about the structure and function of TXA2 receptors.

引用

页码：157 / 161

页数：5

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