HIV INTERACTIONS WITH CD4 - A CONTINUUM OF CONFORMATIONS AND CONSEQUENCES

被引:57
作者
EIDEN, LE [1 ]
LIFSON, JD [1 ]
机构
[1] GENELABS INC, DIV HUMAN IMMUNODEFICIENCY VIRUS & EXPLORAT RES, REDWOOD CITY, CA 94063 USA
来源
IMMUNOLOGY TODAY | 1992年 / 13卷 / 06期
关键词
D O I
10.1016/0167-5699(92)90154-Y
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Here, Lee Eiden and Jeffrey Lifson present a model for HIV envelope glycoprotein-CD4 interactions that attempts to reconcile recent, seemingly conflicting, structural, biochemical and biological observations. Central to this model is the involvement of both the CDR2-like and CDR3-like domains of CD4 in the interaction with gp120, leading to a conformational change and dissociation of gp120 from the gp120-gp41 complex.
引用
收藏
页码:201 / 206
页数:6
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