2 NOVEL ARGININE DERIVATIVES FROM A MUTANT OF STREPTOMYCES-CLAVULIGERUS

被引：23

作者：

ELSON, SW

BAGGALEY, KH

FULSTON, M

NICHOLSON, NH

TYLER, JW

EDWARDS, J

HOLMS, H

HAMILTON, I

MOUSDALE, DM

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT,BETCHWORTH RH3 7AJ,SURREY,ENGLAND

[2] SMITHKLINE BEECHAM PHARMACEUT,WORTHING BN14 8QH,W SUSSEX,ENGLAND

[3] BIOFLUX LTD,ROBERTSON INST BIOTECHNOL,GLASGOW G11 5JS,SCOTLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1993年 / 15期

关键词：

D O I：

10.1039/c39930001211

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two novel arginine derivatives, N2-(2-carboxyethyl)arginine and N2-(2-carboxyethyl)-3-hydroxyarginine, are produced by a mutant of Streptomyces clavuligerus dclH 65, which is blocked in clavulanic acid biosynthesis, and the structures of the compounds indicate that they may be involved in clavulanic acid biosynthesis.

引用

页码：1211 / 1212

页数：2

共 13 条

[1] STUDIES ON THE BIOSYNTHESIS OF CLAVULANIC ACID .5. ABSOLUTE STEREOCHEMISTRY OF PROCLAVAMINIC ACID, THE MONOCYCLIC BIOSYNTHETIC PRECURSOR OF CLAVULANIC ACID [J].