AGE-DIFFERENCES IN BIOCHEMICAL AND HEMATOLOGICAL MEASURES DURING MIDDLE-AGE

被引：7

作者：

BULPITT, CJ

SHIPLEY, MJ

BROUGHTON, PMG

FLETCHER, AE

MARKOWE, HLJ

MARMOT, MG

SEMMENCE, A

机构：

[1] Division of Geriatric Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, W12 ONN, Du Cane Road

[2] Department of Epidemiology and Population Sciences, London School of Hygiene and Tropical Medicine, London

[3] Wolfson Research Laboratories, Queen Elizabeth Medical Centre, Birmingham

[4] Cabinet Office, Office of the Minister for the Civil Service, Medical Advisory Service, Edinburgh

[5] Department of Epidemiology and Public Health, University College, London

来源：

AGING-CLINICAL AND EXPERIMENTAL RESEARCH | 1994年 / 6卷 / 05期

基金：

英国医学研究理事会;

关键词：

AGING; BIOCHEMICAL MEASURES; CHOLESTEROL; HEMATOLOGICAL MEASURES;

D O I：

10.1007/BF03324266

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Biochemical and hematological measures possibly associated with ageing were measured on a single occasion in 3402 male and 2152 female London Civil Servants aged from 35 to 59 years of age. These included erythrocyte sedimentation rate (ESR), blood hemoglobin and serum albumin, calcium, bilirubin, creatinine, urea, urate, high density lipoprotein (HDL), and total cholesterol. Independently and positively related to age were ESR with an estimated 47% 'increase' in men over the 15 years between ages 40 to 55 and a 40% increase in women; serum urea herd a 6%/15-year increase in men and 20% in women; total cholesterol had a 6%/15-year increase in men and 18% in 'increased' by 2%/women; serum creatinine 15-years in men and 5% in women. In women, urate, HDL cholesterol and hemoglobin increased with age group. Negatively related to age was serum bilirubin in both sexes (8% and 6% 'fall'/15-years in men and women respectively). Serum albumin and calcium fell with age group in men. The sexes differed in their relationship to aging for total cholesterol and HDL cholesterol (greater increase in women), serum calcium (small decrease in men and small increase in women), urate and hemoglobin (increases in women but not men). Urea increased more in women than men, and albumin decreased more in men than women (p<0.001 for all comparisons with the exception of HDL cholesterol, p<0.01). Changes during the menopause were thought to explain some of these findings.

引用

页码：359 / 367

页数：9

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